| 1 | Ciro ImmobilePenalty goals: 7 | Lazio | 27 |
| 2 | Dusan VlahovicPenalty goals: 5 | Juventus | 24 |
| 3 | Lautaro MartínezPenalty goals: 3 | Internazionale | 21 |
| 4 | Giovanni SimeonePenalty goals: 0 | Verona | 17 |
| 5 | Tammy AbrahamPenalty goals: 3 | Roma | 17 |
| 6 | Gianluca ScamaccaPenalty goals: 1 | Sassuolo | 16 |
| 7 | Domenico BerardiPenalty goals: 6 | Sassuolo | 15 |
| 8 | Victor OsimhenPenalty goals: 0 | Napoli | 14 |
| 9 | Marko ArnautovicPenalty goals: 2 | Bologna | 14 |
| 10 | Edin DzekoPenalty goals: 0 | Internazionale | 13 |
| 10 | Mario PasalicPenalty goals: 0 | Atalanta | 13 |
| 12 | Gerard DeulofeuPenalty goals: 1 | Udinese | 13 |
| 13 | João PedroPenalty goals: 3 | Cagliari | 13 |
| 14 | Andrea PinamontiPenalty goals: 4 | Empoli | 13 |
| 15 | Gianluca CaprariPenalty goals: 2 | Verona | 12 |
| 16 | BetoPenalty goals: 0 | Udinese | 11 |
| 16 | Francesco CaputoPenalty goals: 0 | Sampdoria | 11 |
| 16 | Rafael LeãoPenalty goals: 0 | Milan | 11 |
| 16 | Sergej Milinkovic-SavicPenalty goals: 0 | Lazio | 11 |
| 20 | Dries MertensPenalty goals: 1 | Napoli | 11 |
| 21 | Olivier GiroudPenalty goals: 2 | Milan | 11 |
| 22 | Antonín BarákPenalty goals: 4 | Verona | 11 |
| 23 | Lorenzo InsignePenalty goals: 9 | Napoli | 11 |
| 24 | Giacomo RaspadoriPenalty goals: 0 | Sassuolo | 10 |
| 25 | Paulo DybalaPenalty goals: 1 | Juventus | 10 |
| 26 | Federico BonazzoliPenalty goals: 2 | Salernitana | 10 |
| 27 | Duván ZapataPenalty goals: 3 | Atalanta | 10 |
| 28 | Mattia DestroPenalty goals: 0 | Genoa | 9 |
| 28 | PedroPenalty goals: 0 | Lazio | 9 |
| 28 | Thomas HenryPenalty goals: 0 | Venezia | 9 |
| 31 | Álvaro MorataPenalty goals: 1 | Juventus | 9 |
| 32 | Lorenzo PellegriniPenalty goals: 2 | Roma | 9 |
| 32 | Luis MurielPenalty goals: 2 | Atalanta | 9 |
| 34 | Zlatan IbrahimovicPenalty goals: 0 | Milan | 8 |
| 35 | Daniele VerdePenalty goals: 1 | Spezia | 8 |
| 35 | Ivan PerisicPenalty goals: 1 | Internazionale | 8 |
| 37 | Andrea BelottiPenalty goals: 3 | Torino | 8 |
| 38 | David OkerekePenalty goals: 0 | Venezia | 7 |
| 38 | Fabián RuizPenalty goals: 0 | Napoli | 7 |
| 38 | Hamed TraorèPenalty goals: 0 | Sassuolo | 7 |
| 38 | Josip BrekaloPenalty goals: 0 | Torino | 7 |
| 38 | Nahuel MolinaPenalty goals: 0 | Udinese | 7 |
| 43 | Antonio CandrevaPenalty goals: 1 | Sampdoria | 7 |
| 44 | Hakan ÇalhanogluPenalty goals: 3 | Internazionale | 7 |
| 44 | Mattia AramuPenalty goals: 3 | Venezia | 7 |
| 44 | Nicolás GonzálezPenalty goals: 3 | Fiorentina | 7 |
| 47 | Antonio SanabriaPenalty goals: 0 | Torino | 6 |
| 47 | Emmanuel Quartsin GyasiPenalty goals: 0 | Spezia | 6 |
| 47 | Felipe AndersonPenalty goals: 0 | Lazio | 6 |
| 47 | Joaquín CorreaPenalty goals: 0 | Internazionale | 6 |