| 1 | Artem DovbykPenalty goals: 7 | Girona | 24 |
| 2 | Alexander SørlothPenalty goals: 0 | Villarreal | 23 |
| 3 | Jude BellinghamPenalty goals: 1 | Real Madrid | 19 |
| 4 | Robert LewandowskiPenalty goals: 4 | Barcelona | 19 |
| 5 | Ante BudimirPenalty goals: 3 | Osasuna | 17 |
| 6 | Youssef En-NesyriPenalty goals: 1 | Sevilla | 16 |
| 7 | Antoine GriezmannPenalty goals: 4 | Atlético de Madrid | 16 |
| 8 | Álvaro MorataPenalty goals: 0 | Atlético de Madrid | 15 |
| 9 | Vinícius JúniorPenalty goals: 1 | Real Madrid | 15 |
| 10 | Borja MayoralPenalty goals: 4 | Getafe | 15 |
| 11 | Gorka GuruzetaPenalty goals: 0 | Athletic Club | 14 |
| 12 | Hugo DuroPenalty goals: 0 | Valencia CF | 13 |
| 12 | Jørgen Strand LarsenPenalty goals: 0 | Celta de Vigo | 13 |
| 14 | Iñaki WilliamsPenalty goals: 0 | Athletic Club | 12 |
| 15 | Myrto UzuniPenalty goals: 4 | Granada CF | 11 |
| 16 | JoseluPenalty goals: 0 | Real Madrid | 10 |
| 16 | RodrygoPenalty goals: 0 | Real Madrid | 10 |
| 16 | Willian JoséPenalty goals: 0 | Real Betis | 10 |
| 19 | Gerard MorenoPenalty goals: 2 | Villarreal | 10 |
| 20 | Ayoze PérezPenalty goals: 0 | Real Betis | 9 |
| 20 | Cristhian StuaniPenalty goals: 0 | Girona | 9 |
| 20 | Samuel AghehowaPenalty goals: 0 | Alavés | 9 |
| 20 | SavinhoPenalty goals: 0 | Girona | 9 |
| 20 | Sergio ArribasPenalty goals: 0 | Almería | 9 |
| 25 | Ángel CorreaPenalty goals: 1 | Atlético de Madrid | 9 |
| 26 | Mikel OyarzabalPenalty goals: 2 | Real Sociedad | 9 |
| 27 | Iago AspasPenalty goals: 3 | Celta de Vigo | 9 |
| 28 | Brahim DíazPenalty goals: 0 | Real Madrid | 8 |
| 28 | Fermín LópezPenalty goals: 0 | Barcelona | 8 |
| 28 | Viktor TsigankovPenalty goals: 0 | Girona | 8 |
| 31 | IscoPenalty goals: 2 | Real Betis | 8 |
| 31 | Mason GreenwoodPenalty goals: 2 | Getafe | 8 |
| 33 | Anastasios DouvikasPenalty goals: 0 | Celta de Vigo | 7 |
| 33 | Ferran TorresPenalty goals: 0 | Barcelona | 7 |
| 33 | Joao FélixPenalty goals: 0 | Barcelona | 7 |
| 33 | José Luis MoralesPenalty goals: 0 | Villarreal | 7 |
| 33 | PortuPenalty goals: 0 | Girona | 7 |
| 33 | Takefusa KuboPenalty goals: 0 | Real Sociedad | 7 |
| 39 | Alex BerenguerPenalty goals: 1 | Athletic Club | 7 |
| 39 | Vedat MuriqiPenalty goals: 1 | Mallorca | 7 |
| 41 | PepeluPenalty goals: 7 | Valencia CF | 7 |
| 42 | Abdón PratsPenalty goals: 0 | Mallorca | 6 |
| 42 | Álvaro GarciaPenalty goals: 0 | Rayo Vallecano | 6 |
| 42 | Arda GülerPenalty goals: 0 | Real Madrid | 6 |
| 42 | Kirian RodríguezPenalty goals: 0 | Las Palmas | 6 |
| 42 | Léo BaptistãoPenalty goals: 0 | Almería | 6 |
| 42 | Lucas BoyéPenalty goals: 0 | Granada CF | 6 |
| 42 | Marcos LlorentePenalty goals: 0 | Atlético de Madrid | 6 |
| 42 | Raúl GarcíaPenalty goals: 0 | Osasuna | 6 |
| 50 | Bryan ZaragozaPenalty goals: 1 | Granada CF | 6 |